Epigenetics and the exposomes: Obesity and beyond

Rita P Raman


The specific genetic alterations that result in diseases and complex syndromes have been and continue to be
identified. Search for the origins of disease have led to investigations into the roles of dietary and environmental
factors as potential triggers or modifiers of risk. Genome-wide association studies have identified concepts such
as the rare variant-common disease hypothesis and the common variant-common disease hypothesis.1 Through
association studies, unique gene-environment interactions, which may occur with or without specific periods
of permissiveness or vulnerabilities, have also been identified. Major conditions where the role of exposomes
and epigenetics are rapidly evolving are obesity, neurological disorders, immune disorders and cancers. These
concepts are particularly intriguing in the context of obesity.


Epigenetics exposomes Obesity

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DOI: http://dx.doi.org/10.22565/ijn.v6i3.108


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