Assessment of the scientific evidence of the potential use of açaí (Euterpe oleracea, Mart.) in clinical outcomes: analysis with focus on antioxidant and anti-inflammatory action

Amanda de Menezes Figueiredo, Igor Ribeiro de Castro Biernet

Abstract


The açaí berry (Euterpe oleracea, Mart.), fruit native to the Amazon region and explored mainly in the region
of Pará, gained importance in recent years due to potential health benefits, associated with its phytochemical
composition and antioxidant capacity, related to its high content of flavonoids. Among these, anthocyanins are
responsible for the anti-inflammatory and antioxidant capacity of this fruit. Experimental studies show that due to
its composition, the acai berry has antioxidant activity related to its ability to reduce the reactive oxygen species
(ROS) and its potential to inhibit cyclooxygenase 2 (COX-2). Another benefit studied is the analysis of their
effectiveness in the anti-inflammatory process, being observed inhibition of araquedônico acid-derived mediators,
suggesting that the fruit can act in the chronic inflammatory process. Also it was possible to observe that the
fruit may have anti-inflammatory effects in healthy patients. Thus, the supplementation of diets with use of acai
berry could attenuate inflammation process and oxidative stress, today with more consistent evidence derived
primarily from in vitro studies. However, there is still need for further studies to prove the action of this fruit in the
mechanisms involved in these processes, isolation of specific compounds and determining their optimal dosage.

Keywords


Fruits, Antioxidants, Anti-inflammatories

Full Text:

PDF PDF

References


Menezes N, Varela P, Furtado A, Couceiro A, Calheiros I, Rosado

L, et al. Chromoblastomycosis associated with Fonsecaea

pedrosoi in a carpenter handling exotic woods. Dermatology

online journal. 2008;14(2):9. Epub 2008/08/14. PubMed

PMID: 18700112.

Sistema de Produção do Açaí: Composição química do açaí

[Internet]. 2006 [cited 27 abr. 2013]. Available from: http://

sistemasdeproducao.cnptia.embrapa.br/FontesHTML/Acai/

SistemaProducaoAcai_2ed/paginas/composicao.htm.

Rogez G, Marvilliers A, Riviere E, Audiere JP, Lloret F, Varret

F, et al. A Mixed-Valence Mixed-Spin Prussian-Blue-Like

Heptanuclear Complex We are indebted to Prof. P. Day of The

Royal Institute of Great Britain for interesting discussions that

were at the origin of the work presented in this paper. Angewandte

Chemie. 2000;39(16):2885-7. Epub 2000/10/12. PubMed

PMID: 11027998.

Portinho JAZ, L. M.; Bruck. M. R. Beneficial effects of açaí.

International Journal of Nutrology, . 2012;5(1):15-20. Epub

jan./abr. 2012.

Sistema de Produção do Açaí: Sistema de Produção do Açaí

[Internet]. 2006 [cited 24 jun 2013]. Available from: http://

sistemasdeproducao.cnptia.embrapa.br/FontesHTML/Acai/

SistemaProducaoAcai_2ed/paginas/processamento.htm.

Sabbe S, Verbeke W, Deliza R, Matta VM, Van Damme P.

Consumer liking of fruit juices with different acai (Euterpe

oleracea Mart.) concentrations. Journal of food science.

;74(5):S171-6. Epub 2009/08/04. doi: 10.1111/j.1750-

-3841.2009.01146.x. PubMed PMID: 19646053.

Kim YS, Jung H, Zerin T, Song HY. Protein profiling of

paraquat-exposed rat lungs following treatment with Acai

(Euterpe oleracea Mart.) berry extract. Molecular medicine

reports. 2013;7(3):881-6. Epub 2013/01/08. doi: 10.3892/

mmr.2013.1259. PubMed PMID: 23291665.

APC. C. Avaliação do efeito da extração e da microfiltração do

açaí sobre sua composição e atividade antioxidante. [Tese de

Mestrado]: Universidade Federal do Rio de Janeiro; 2008.

Sposito AC, Caramelli B, Fonseca FA, Bertolami MC, Afiune

Neto A, Souza AD, et al. [IV Brazilian Guideline for Dyslipidemia

and Atherosclerosis prevention: Department of Atherosclerosis

of Brazilian Society of Cardiology. Arquivos brasileiros

de cardiologia. 2007;88 Suppl 1:2-19. Epub 2007/05/23. Pub-

Med PMID: 17515982.

Turner A, Okubo Y, Teramura S, Niwa Y, Ibaraki K, Kawasaki

T, et al. The antioxidant and non-antioxidant contributions of

vitamin E in vitamin E blended ultra-high molecular weight

polyethylene for total knee replacement. Journal of the mechanical

behavior of biomedical materials. 2012. Epub 2013/02/02.

doi: 10.1016/j.jmbbm.2012.12.006. PubMed PMID: 23369759.

Rembold CM. Review: Vitamin and antioxidant supplements

do not prevent adverse cardiovascular events. Annals of internal

medicine. 2013;158(12):JC10. Epub 2013/06/20. doi:

7326/0003-4819-158-12-201306180-02010. PubMed

PMID: 23778922.

ESLT M. Influência da sazonalidade sobre a composição química

e atividade antioxidante do açaí (Euterpe oleracea Mart.)

[Tese de doutorado]: Universidade Federal do Amapá; 2011.

Beara IN, Lesjak MM, Jovin ED, Balog KJ, Anackov GT, Orcic

DZ, et al. Plantain (Plantago L.) species as novel sources

of flavonoid antioxidants. Journal of agricultural and food chemistry.

;57(19):9268-73. Epub 2009/09/17. doi: 10.1021/

jf902205m. PubMed PMID: 19754195.

Leong ACN KY, Tako M, Iwasaki H, Oku H, Tamaki H. Flavonoid

glycosides in the shoot system of Okinawa Taumu (Colocasia

esculenta S.). Food Chemistry. 2010;119(2):630-5.

Li C, Du H, Wang L, Shu Q, Zheng Y, Xu Y, et al. Flavonoid

composition and antioxidant activity of tree peony (Paeonia

section moutan) yellow flowers. Journal of agricultural and

food chemistry. 2009;57(18):8496-503. Epub 2009/08/29. doi:

1021/jf902103b. PubMed PMID: 19711909.

Kang J LZ, Wu T, Jensen GS, Schauss AG, Wu X. Anti-oxidant

capacities of flavonoid compounds isolated from acai pulp (Euterpe

oleracea Mart.). Food Chemistry 2010;122:610-7. Epub

/03/03.

Graf D, Seifert S, Jaudszus A, Bub A, Watzl B. Anthocyanin-

-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin

and Improves Plasma Fatty Acid Composition in Fischer Rats.

PloS one. 2013;8(6):e66690. Epub 2013/07/05. doi: 10.1371/

journal.pone.0066690. PubMed PMID: 23825152; PubMed

Central PMCID: PMC3688949.

Wang D, Xia M, Yan X, Li D, Wang L, Xu Y, et al. Gut microbiota

metabolism of anthocyanin promotes reverse cholesterol

transport in mice via repressing miRNA-10b. Circulation

research. 2012;111(8):967-81. Epub 2012/07/24. doi: 10.1161/

CIRCRESAHA.112.266502. PubMed PMID: 22821931.

Qin Y, Xia M, Ma J, Hao Y, Liu J, Mou H, et al. Anthocyanin

supplementation improves serum LDL- and HDL-cholesterol

concentrations associated with the inhibition of cholesteryl ester

transfer protein in dyslipidemic subjects. The American journal

of clinical nutrition. 2009;90(3):485-92. Epub 2009/07/31. doi:

3945/ajcn.2009.27814. PubMed PMID: 19640950.

Han KH, Matsumoto A, Shimada K, Sekikawa M, Fukushima

M. Effects of anthocyanin-rich purple potato flakes on antioxidant

status in F344 rats fed a cholesterol-rich diet. The British

journal of nutrition. 2007;98(5):914-21. Epub 2007/06/15. doi:

1017/S0007114507761792. PubMed PMID: 17559701.

Xia M, Ling W, Zhu H, Wang Q, Ma J, Hou M, et al. Anthocyanin

prevents CD40-activated proinflammatory signaling in endothelial

cells by regulating cholesterol distribution. Arteriosclerosis,

thrombosis, and vascular biology. 2007;27(3):519-24.

Epub 2006/12/13. doi: 10.1161/01.ATV.0000254672.04573.2d.

PubMed PMID: 17158355.

Pompeu DR, Silva EM, Rogez H. Optimisation of the solvent

extraction of phenolic antioxidants from fruits of Euterpe oleracea

using Response Surface Methodology. Bioresource technology.

;100(23):6076-82. Epub 2009/07/08. doi: 10.1016/j.

biortech.2009.03.083. PubMed PMID: 19581082.

Santos GM, Maia GA, Sousa PH, Costa JM, Figueiredo RW, Prado

GM. [Correlation between antioxidant activity and bioactive

compounds of acai (Euterpe oleracea Mart) comercial pulps].

Archivos latinoamericanos de nutricion. 2008;58(2):187-92.

Epub 2008/10/07. PubMed PMID: 18833997.

Vissotto LC RE, Chisté RC, Benassi MT, Mercadante AZ. Correlation,

by multivariate statistical analysis, between the scavenging

capacity against reactive oxygen species and the bioactive

compounds from frozen fruit pulps3. Ciência e Tecnologia

de Alimentos. 2013;33(Supl. 1):57-65.

Gouvêa ACMS AM, Schulz DF, Pacheco S, Godoy RLO, Cabral

LMC. Anthocyanins standards (cyanidin-3-O-glucoside

and cyanidin-3-O-rutinoside) isolation from freeze-dried açaí

(Euterpe oleraceae Mart.) by HPLC. Ciência e Tecnologia de

Alimentos. 2012;32 (1):43-6. Epub jan.-mar. 2012.

Mertens-Talcott SU, Rios J, Jilma-Stohlawetz P, Pacheco-Palencia

LA, Meibohm B, Talcott ST, et al. Pharmacokinetics of

anthocyanins and antioxidant effects after the consumption of

anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.)

in human healthy volunteers. Journal of agricultural and food

chemistry. 2008;56(17):7796-802. Epub 2008/08/13. doi:

1021/jf8007037. PubMed PMID: 18693743.

Cardoso LM LJ, Peluzio MCG. Efeitos biológicos das antocianinas

no processo aterosclerótico. Revista Colombiana de

Ciências Químico Farmacêutica. 2011;40(1):116-38. Epub

/05/30.

Noratto GD, Angel-Morales G, Talcott ST, Mertens-Talcott

SU. Polyphenolics from acai ( Euterpe oleracea Mart.) and

red muscadine grape (Vitis rotundifolia ) protect human umbilical

vascular Endothelial cells (HUVEC) from glucose- and

lipopolysaccharide (LPS)-induced inflammation and target

microRNA-126. Journal of agricultural and food chemistry.

;59(14):7999-8012. Epub 2011/06/21. doi: 10.1021/

jf201056x. PubMed PMID: 21682256.

Pacheco-Palencia LA, Mertens-Talcott S, Talcott ST. Chemical

composition, antioxidant properties, and thermal stability of a

phytochemical enriched oil from Acai (Euterpe oleracea Mart.).

Journal of agricultural and food chemistry. 2008;56(12):4631-

Epub 2008/06/05. doi: 10.1021/jf800161u. PubMed PMID:

Feio CA, Izar MC, Ihara SS, Kasmas SH, Martins CM, Feio

MN, et al. Euterpe oleracea (acai) modifies sterol metabolism

and attenuates experimentally-induced atherosclerosis. Journal

of atherosclerosis and thrombosis. 2012;19(3):237-45. Epub

/12/06. PubMed PMID: 22139433.

Ribeiro JC AL, Aissa AF, Darin JDC, de Rosso VV, Mercadante

AZ, Bianchi MLP. Evaluation of the genotoxic and antigenotoxic

effects after acute and subacute treatments with açai

pulp (Euterpe oleracea Mart.) on mice using the erythrocytes

micronucleus test and the comet assay. Mutation research.

;695(1-2):22-8. Epub 2009/11/03.

Rogez H, Akwie SN, Moura FG, Larondelle Y. Kinetic modeling

of anthocyanin degradation and microorganism growth during

postharvest storage of acai fruits (Euterpe oleracea). Journal

of food science. 2012;77(12):C1300-6. Epub 2012/12/18.

doi: 10.1111/j.1750-3841.2012.02996.x. PubMed PMID:

Guerra JF, Magalhaes CL, Costa DC, Silva ME, Pedrosa ML.

Dietary acai modulates ROS production by neutrophils and

gene expression of liver antioxidant enzymes in rats. Journal

of clinical biochemistry and nutrition. 2011;49(3):188-94.

Epub 2011/12/01. doi: 10.3164/jcbn.11-02. PubMed PMID:

; PubMed Central PMCID: PMC3208015.

Fragoso MF, Romualdo GR, Ribeiro DA, Barbisan LF. Acai

(Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-

-induced rat colon carcinogenesis. Food and chemical toxicology

: an international journal published for the British Industrial

Biological Research Association. 2013;58C:68-76. Epub

/04/20. doi: 10.1016/j.fct.2013.04.011. PubMed PMID:

Poulose SM, Fisher DR, Larson J, Bielinski DF, Rimando

AM, Carey AN, et al. Anthocyanin-rich acai (Euterpe oleracea

Mart.) fruit pulp fractions attenuate inflammatory stress signaling

in mouse brain BV-2 microglial cells. Journal of agricultural

and food chemistry. 2012;60(4):1084-93. Epub 2012/01/10.

doi: 10.1021/jf203989k. PubMed PMID: 22224493.

Favacho HAS OB, Santos KC, Medeiros BJL, Sousa PJC, Perazzo

FF, Carvalho JCT. Anti-infl ammatory and antinociceptive

activities of Euterpe oleracea oil. Brazilian Journal of Pharmacognosy.

;21(1):105-14. Epub 2011/01/24.

da Costa CA, de Oliveira PR, de Bem GF, de Cavalho LC, Ognibene

DT, da Silva AF, et al. Euterpe oleracea Mart.-derived

polyphenols prevent endothelial dysfunction and vascular

structural changes in renovascular hypertensive rats: role of

oxidative stress. Naunyn-Schmiedeberg’s archives of pharmacology.

;385(12):1199-209. Epub 2012/10/12. doi:

1007/s00210-012-0798-z. PubMed PMID: 23052352.

Jensen GS, Wu X, Patterson KM, Barnes J, Carter SG,

Scherwitz L, et al. In vitro and in vivo antioxidant and anti-

-inflammatory capacities of an antioxidant-rich fruit and berry

juice blend. Results of a pilot and randomized, double-blinded,

placebo-controlled, crossover study. Journal of agricultural and

food chemistry. 2008;56(18):8326-33. Epub 2008/08/23. doi:

1021/jf8016157. PubMed PMID: 18717569.

Ellinger S, Gordon A, Kurten M, Jungfer E, Zimmermann BF,

Zur B, et al. Bolus consumption of a specifically designed fruit

juice rich in anthocyanins and ascorbic acid did not influence

markers of antioxidative defense in healthy humans. Journal

of agricultural and food chemistry. 2012;60(45):11292-300.

Epub 2012/10/18. doi: 10.1021/jf300719t. PubMed PMID:

Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of Acai

(Euterpe oleracea Mart.) berry preparation on metabolic parameters

in a healthy overweight population: a pilot study. Nutrition

journal. 2011;10:45. Epub 2011/05/17. doi: 10.1186/1475-

-10-45. PubMed PMID: 21569436; PubMed Central

PMCID: PMC3118329.

Jensen GS, Ager DM, Redman KA, Mitzner MA, Benson

KF, Schauss AG. Pain reduction and improvement in range of

motion after daily consumption of an acai (Euterpe oleracea

Mart.) pulp-fortified polyphenolic-rich fruit and berry juice

blend. Journal of medicinal food. 2011;14(7-8):702-11. Epub

/04/08. doi: 10.1089/jmf.2010.0150. PubMed PMID:

; PubMed Central PMCID: PMC3133683.




DOI: http://dx.doi.org/10.22565/ijn.v7i2.141

Refbacks

  • There are currently no refbacks.