Nutrology and type 2 diabetes: Nutrient pathophysiology and the transition from health to disease

Eugenio Cersosimo, José Eduardo Dutra de Oliveira


From a Nutrology point of view, type 2 diabetes is a multi-factorial form of clinical “malnutrition” resulting from theintake of an imbalanced diet in combination with adverse environmental conditions and in the presence ofpredisposing genetic factors. In this review article, we present evidence of a close association between clinicalobesity in a specific genetic background as the pillars of the process underlying the development of type 2 diabetes.We review the basics of the energy balance and the role of fat storage and body distribution in the pathogenesis ofinsulin resistance. We describe some molecular aspects of nutrients under normal physiology and during themetabolic and hormonal abnormalities that accompany type 2 diabetes. We conclude with a brief discussion of theprinciples behind popular dietary recommendations aimed at preventing the full development of diabetes mellitusand its complications.


Type 2 Diabetes, Nutrient Patho-physiology; Genetics and Obesity

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